Marcus Rashford scored on his 100th Premier League appearance on Sunday to secure a 1-0 win over Leicester City that kept interim manager Ole Gunnar Solskjaer's dream start going at his old club.
With the league paused for the international break, Ronaldo is expected to play his first game when United host Newcastle United at old Trafford on September 11.
Goalkeeper De Gea was forced to leave the field during Spain's Euro 2020 qualifier against Sweden on Tuesday.
'Solskjaer has improved morale by freeing players from the shackles with which Mourinho had bound them.' 'He has made his team a happier bunch of people,' says Suhit K Sen.
News of all that's transpired on and off the football field
The win extends United's unbeaten run in all competitions to 14 matches and secures a 30th appearance in the last four of the FA Cup for the club.
City boss Pep Guardiola was named Manager of the Season for a third time.
United are unbeaten in all competitions since Solskjaer replaced Jose Mourinho in December and their improvement is down to the Norwegian's insistence on an attacking style of play, as opposed to the defensive fare served up by his predecessor.
Is VAR sucking the life out of the game?
Sixth-placed United's chances of finishing in the top four were dealt a blow at Goodison Park and the nature of Sunday's defeat prompted manager Ole Gunnar Solskjaer to issue an apology to fans ahead of the clash with their city rivals.
News of all that transpired on and off the football field.
Paul Pogba's future at Manchester United caught up in a swirl of speculation.
The Spaniard has made a number of uncharacteristic mistakes in recent games, including one that allowed Chelsea to equalise in Sunday's 1-1 draw.
Pep Guardiola said Manchester United's home ground Old Trafford is no longer the fortress it used to be as City look to win all three points and take the lead in the Premier League title race.
Saturday's 2-1 FA Cup quarter-final defeat at Wolverhampton Wanderers followed a 2-0 loss at Arsenal last week.
Manchester United have named German Ralf Rangnick as interim manager until the end of the season, the Premier League club announced on Monday, eight days after sacking Ole Gunnar Solskjaer.
Manchester United's interim manager Ralf Rangnick has been appointed as the Austrian national team coach on a two-year deal tasked with qualifying for Euro 2024.
United youth product Gomes, 18, struck after Spurs' Lucas Moura cancelled out Anthony Martial's first-half opener and gave the 20-time Premier League champions another victory after they beat Perth Glory, Leeds United and Inter Milan.
United led through Juan Mata's 11th minute strike but just before halftime the visitors were level when De Gea weakly parried an Antonio Rudiger shot into the path of Marcos Alonso.
News of all that's transpired on and off the football field
After a string of middling transfer windows, Manchester United have made their biggest statement of intent in recent years by signing centre back Raphael Varane and winger Jadon Sancho.
For all their improvement under Klopp, European champions Liverpool have not won at Old Trafford under the German
Headed goals from Anthony Martial and captain Harry Maguire earned Manchester United a hard-fought 2-0 win at toothless Chelsea on Monday amid more VAR controversy, putting them back in the hunt for a top-four Premier League finish. The VAR system made the headlines once again after two Chelsea efforts were ruled out and England international Maguire escaped sanction for a kick out at Michy Batshuayi.
'My ancestors and my parents suffered for my generation to be free today, to work, to take the bus, to play football'
Five talking points from the Premier League weekend:
IMAGES from the English Premier League match between Liverpool and Manchester United at Old Trafford on Sunday
Manchester United signed Netherlands midfielder Donny van de Beek from Ajax Amsterdam on a five-year contract, the English Premier League club said on Wednesday.
He made history during their opening group match, as Salzburg hammered Genk 6-2.
Pogba re-signed for United from Juventus in 2016 but failed to deliver on his huge promise
Dean Henderson arrived at the club from Carlisle United at the age of 14,
Chelsea have condemned online racist abuse aimed at defender Reece James and called on social media platforms to take tougher action against users who engage in such 'despicable behaviour'.
Pochettino picks Barcelona as favourites to win Champions League
A summary of Saturday's action in the Premier League.
'Every time he plays for us he is improving. He's a great athlete, wins his challenges and is quick on his feet. He started settling us to be fair'
Manchester United midfielder Paul Pogba has thanked Jose Mourinho for helping him 'improve as a person' despite the breakdown of their relationship in the last few months leading up to the former manager's sacking on Tuesday.
News of all that's transpired on and off the football field
A weakened Manchester United were beaten 2-1 at home by Leicester City on Tuesday, ending Manchester City's wait to be crowned Premier League champions.
Second-placed Manchester United edged closer towards qualification for the Champions League
Paul Pogba believes the Red Devils have right balance to win FA Cup and Europa League crowns.
Cristiano Ronaldo passed the 800-goal mark for club and country, scoring twice as Manchester United beat Arsenal 3-2 in an incident-packed Premier League match on Thursday.